PAT for Hot Melt Extrusion (HME)

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Is the API dispersed and homegenically distributed in the polymer matrix?

What is the residence time and what influence does it have on the API?

Is the dosage of the API constant and uniform?

Crystalline or amorphous which is present?

These questions and many more in hot melt extrusion of pharmaceuticals and formulation development can be realized with InSpectro X our UV-Vis inline spectrophotometer in R&D work. It saves enormous time and offers fast data analysis capabilities.

Beside the UV-Vis, we also offer NIR and RAMAN as inline spectrometers for hot melt extrusion with the appropriate fiber optic probes and as „GiANT“ the world’s first „3in1“ spectrometer platform.

ColVisTec cooperates with the world's leading manufacturers in the paint, pharmaceutical, plastics and chemical industries. Our team of highly experienced engineers and scientists support these industries with reliable and industry-standard inline spectroscopy solutions combined with fiber optic probes for continuous process monitoring.

With the integration of inline spectrophotometers into production lines, the final processed product is measured directly in the process. This allows the entire production process to be monitored seamlessly in real time, based on the measurement data of the manufactured product. The production process is not disturbed, no samples are taken. This allows to achieve increases in productivity and quality. It becomes an integral part of digitalized manufacturing.

Our technology can be integrated into a wide range of processes. For this purpose, we combine our spectrometers with different probes for liquid, pasty, powdery or molten media in the process for temperatures up to 400 °C (752 °F) and process pressures up to 250 bar (3625 psi). With the standardized solutions it can be integrated very easily and quickly into existing production lines. Flexible hardware configurations and data output in various formats are possible.

Comprehensive and competent customer support as well as training options ensure a smooth transition from cumbersome, time- and labor-intensive offline measurement to fully automated inline process monitoring.

From our headquarters in Berlin, Germany, we support our products worldwide and work closely with our customers. In addition, we cooperate with other process equipment manufacturers to offer complete solutions. Usually our technology is integrated into existing production lines to increase their productivity and quality. We do not see ourselves as a hardware supplier, but as a provider of unique solutions that are specifically tailored to the processes of the customers.

We look forward to learn about your batch or continuous process and discuss the details for an inline process monitoring solution.

Realized applications: Plastics industry (compounding, reactive extrusion, recycling, powder coating, etc.), pharmaceutical industry as PAT in hot melt extrusion, paints and coatings industry in liquid media, etc.