COMBER Process Technology S.r.l.

COMBER Pressofiltro® Series PF 100 - PF 10000 Pharmaceutical design

COMBER Pressofiltro nutsche filters or filter dryers are versatile units designed for multipurpose production facilities. To meet the demanding requirements for filters used in the manufacture of pharmaceutical ingredients, the filters are designed to meet stringent cGMP and FDA guidelines.

Special properties for the customer’s benefit:

• Excellent cleanability using CIP systems, simple validation
• Openable filter base provides for good access to the filter internals for cleaning and inspection
• Easily interchangeable filter plates, with flat, homogeneous filter surfaces for good cleanability and inspection
• Multilayer and/or conventional filter materials
• Good drying performance with special agitator design, large heat exchange areas
• Double mechanical seals, externally interchangeable, dry running contacting or non-contacting lift-off type seals as well as liquid lubricated seals

COMBER Pressofiltro® - Series PF 2000 - PF 16000 Chemical design

Chemical design Pressofiltro® agitated Nutsche filters, suction filters or filter dryers are versatile units equally suited for monoproduction applications and for multipurpose production facilities.

Special properties for the customer’s benefit:

• Available as closed units with manhole access or with an openable filter base
• Multilayer and/ or conventional filter materials
• Good emptying characteristics due to narrow agitator to wall/ bottom clearances and a unique agitator blade design
• Shaft seal with externally accessible stuffing box
   

Sterilizable Filter Dryer

COMBER Pressofiltro® Series PF 50 - PF 6000 Steam Sterilizable Design

COMBER Pressofiltro steam sterilizable agitated Nutsche filter dryers are designed to maintain full sterility during the entire process, from inerting through slurry feeding and filtration, washing and drying to discharge of the dry product. CIP and SIP provide a very effective, safe and convenient form of sterilization, easy to automate and validate.

Special properties for the customer’s benefit:

• With Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) systems designed for the automatic cleaning and disinfecting of the equipment
• Steam sterilizable filter dryer design assures steam reaches all parts of the filter dryer in contact with the product and air is not trapped in the unit during sterilization
• In compliance with cGMP and FDA guidelines, with vessel interior and all associated piping designed to prevent product adherence and to facilitate cleanability, fully drainable for clearance of condensate during the heating process, with aseptic design for flanges, seals, valves etc.
• Double mechanical seals, externally interchangeable, dry running with debris well, steam sterilizable

Filter Dryer with Containment System

COMBER Pressofiltro® Series PF 50 - PF 2000 with Containment System

Pressofiltro® agitated Nutsche filters or filter dryers with containment system provide protection of the operators against hazardous materials and equally provide product or process safety against possible contamination from external particles.

Special properties for the customer’s benefit:

• Containment systems (glove boxes) are designed to allow contamination free sampling, product discharge, heel removal and product pack-off into suitable containers
• Containment systems are available as passive, active, single chamber, two chamber and multiple chamber designs, all in compliance with cGMP and FDA guidelines
• Active isolator units are equipped with air handling systems and HEPA inlet and exhaust filters for containment levels down to 10 ng/m³ TWA
• The isolator design permits sampling, product discharge, pack-off, heel removal and filter cloth disposal in a single unit
• Sample and small items transfer using optional RTP‘s (Rapid Transfer Ports/alpha-beta ports), split butterfly valves, bag-in/ bag-out port

COMBER Turbodry® - Series TD 0.8/1.1 - TD 60/100

The Turbodry agitated vacuum pan dryer has proven to be excellent for the drying of sensitive, pasty and other “diffcult” products that pass through a highly viscous stage during the drying process. The dryers have proven to be particularly suited for the drying of heat sensitive products as well as products with fragile crystal structure and thus sensitive to shear forces. Excellent product discharge and shortest cycle times.

Special properties for the customer’s benefit:

• In compliance with cGMP and FDA guidelines, also in aseptic/ steam sterilizable versions
• Shortest possible drying times, suitable for the drying of sensitive, pasty, sticky and other “diffcult” products such as those turning highly viscous during the drying process
• Simultaneous axial and radial agitator movements permit uniform mixing of the entire product mass, without the formation of lumps or balls
• Double mechanical seal, dry running contacting or non-contacting lift-off or liquid lubricated, externally interchangeable
• Agitator supported by the top head, with the seal in contact with the vapors only

COMBER Condry® - Series TDC 25 - TDC 15000

The Condry conical bottom agitated vacuum dryer was developed to process a wide variety of products. The machines have proven to be particularly suited for the drying of heat sensitive products as well as products with fragile crystal structure and thus sensitive to shear forces. The conical bottom allows for full product discharge characteristics.

Special properties for the customer’s benefit:

• In compliance with cGMP and FDA guidelines, also in aseptic/ steam sterilizable versions
• Excellent product discharge performance with negligible product hold-up due to the conical vessel bottom, very close agitator to wall/bottom clearances and a unique agitator design
• The agitator permits uniform mixing of the entire product mass, without the formation of lumps or balls
• The surface area for heat transfer is maximized for optimum performance and cycle times
• Agitator supported by the top head, with the seal in contact with the vapors only
• Entirely welded agitator design, without any bolts, without pockets and with all edges rounded for good cleanability

COMBER Pharmadry® - Series PH 50 - PH 4000

The Pharmadry vacuum paddle dryer with short drying times is well suited for the drying of freely flowing, sensitive pharmaceutical ingredients and fine chemicals. Designed to meet stringent cGMP and FDA guidelines.

Special properties for the customer’s benefit:

• In compliance with cGMP and FDA guidelines, also in aseptic/ steam sterilizable versions
• Agitator supported at the rear, with externally exchangeable mechanical seal
• Entirely welded agitator design, without any bolts, without pockets and with all edges rounded for good cleanability
• Minimal build depth, thus very good accessibility for inspection and cleaning purposes
• Excellent cleanability using CIP systems, simple validation
• Available with separating wall between process and mechanical areas
• Double mechanical seal, externally interchangeable, dry running contacting or non-contacting lift-off type seals as well as liquid lubricated seals

COMBER Termomix® Series TM 1000 - TM 40000

The Termomix vacuum paddle dryer/reactor is intended for monoproduction applications or bulk production facilities as mixer, reactor, precipitator and dryer.

Special properties for the customer’s benefit:

• Economic, robust multipurpose machine for heavy industrial applications
• The agitator is supported on both ends providing excellent mixing characteristics, with externally interchangeable stuffing boxes or mechanical seals
• Large heating area resulting in an outstanding heat transfer rate by heating the vessel walls, the vessel ends as well as the agitator shaft and arms