The containment of the formulation activities of HPAPI Oral Solid Forms requires high integration with the process machines without affecting their functionalities and performance. The goal is to guarantee to the operator the best use of the process machines assuring high containment capability.
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The process is kept separated from the environment by means of closed rigid walls around the formulation machines. Suitable air barriers are provided when continuous operations are requested. Dedusting machines and powder suction units are proposed to be integrated inside the isolators to provide a higher containment.
Negative pressure regimes with turbulent airflows are generally adopted. Isolators are generally supplied with glove ports configuration. It is possible to reach containment levels down to 0,01mg/m3.
Typical applications are spray dryers, , granulators, extruders, mixers, powder screens, tablet presses, capsules filling and pan coating machines.
Isolators for additional services in OSD departments include: dispensing, In Process Quality Control (IPC) and HPLC preparations.