Bausch + Ströbel Maschinenfabrik GmbH + Co. KG

More possibilities in small batch production
Machine designs entirely suitable for use in an isolator

Bausch+Ströbel has built small, semi-automatic machines for small-batch production – mostly in laboratories – right from the start. Their special feature is that they employ the same filling and sealing technologies as high-speed machines. Now, Bausch+Ströbel has completely revised these “little ones”. The most interesting novelty: They have been designed to meet all requirements for use in an isolator. All components are resistant to VHP sterilization; they are not affected by vaporized hydrogen peroxide at all. The new small models are the perfect supplement for the flexible production system VarioSys - an isolator system of interchangeable machine modules allowing different combinations as required.

The „new littles ones“ that can be used to process bottles, vials, cartridges, syringes and test tubes, do not only feature the suitability for use in an isolator, they can do more than their predecessors: for example, the control system has been completely upgraded. All adjustments can be carried out on a touch screen. Parameters such as speed, position or filling quantity can also be stored and filed there as so-called recipes. All movements are servomotor controlled. The optional filling needle movement allows bottom-up filling with the needle immersed thereby ensuring gentle handling of the product.

In addition to the basic models, all models are now also available in enhanced versions offering even more sophistication. It is possible, for example, to integrate 100% IPC with scales. Dosing is carried out directly on the scales. The filling quantity is automatically adjusted during production. Batch logs can be stored, and an interface for a printer is also available

It is the L-shaped design that all new semi-automatic machines have in common. They are not only easy to clean but can also be used in an isolator as they easily withstand the sterilization process inside the isolator. Each individual machine can also be operated with gloves.
This allows interesting combinations with the modular system VarioSys . The VarioSys is a small, space-saving system which can handle different products and batches in an isolator in quick succession due to short changeover times. The principle of this new solution is quite simple: A special isolator for production under clean room class A conditions can be combined with different production modules. The respective production module can be easily rolled out from the isolator - just like a workbench - and then be replaced by a different one. A special inflatable seal ensures the secure and gas-tight connection between isolator and production module.
One of these special production modules can be equipped individually with all kinds of laboratory apparatus or with semi-automatic machines according to the requirements. It can accommodate two semi-automatic machines of the new series.
 

Bausch+Ströbel’s versatile VarioSys production system addresses the pharmaceutical industry’s need for space-saving equipment that can be quickly reconfigured for different packaging materials and medicines.
Since it was first launched in 2013, VarioSyshas been steadily expanded –and is now an established brand in the industry. Originally developed jointly with BöhringerIngelheim, the product essentially consists of two components:
• a standardizedSkancleanroom isolator and
• a similarly standardized, interchangeableBausch+Ströbelmachine module that works on the key-lock principle.


VarioSysis just as suitable for use in the laboratory as it is in a fully automatic, low-volume production line thanks to the in-line connectivity of the isolator chambers.
VarioSysmachine modules are available for the processing of vials, syringes, cartridges and ampoules.
These can be processed both as RTU containers packed in nests and tubs or trays or as bulkwarein combination with a Bausch+Ströbelcleaning machine and sterilizing tunnel. A module for filling IV bags can be supplied by Harro Höfliger.

New Module for RTU-Vials
VarioSysis now even more user-friendly thanks to a module for fully automatic tub opening and RTU vial denesting.. Used in combination with the KSF5105 bulk filling and closing system, this new module offers fully automatic in-nest opening (tubs), denesting, filling, stoppering, crimp capping and tray loading of RTU vials. As a result, nested vials can now be processed with 100% In Process Control (IPC) at maximum machine output.

Flexible and expandable

Customers who choose VarioSysare opting not so much for a machine as a system solution. For example, a system originally only used for bulk processing can now also be employed to process RTU syringes simply by adding a nest filling module. The line concept can be expanded at any time with isolators, machine modules and freeze dryers.