26 - 28 September 2017 // Nuremberg, Germany

Posting print layout

What information should be shown in the print layout?

Create print layout
Zoom product LOGO_Powder expertise

Powder expertise

LOGO_Powder expertise

Powder expertise

Request information Request information

Contact us

Please enter your personal information and desired appointment. You can also leave us a message.

Your personal information

Your message for us

Desired appointment during the exhibition

* Compulsory fields you must fill in.
Your message has been sent.

Would you like to use more facilities and advantages of the platform? Then please log in – or register here.

An error has occurred.

Handling and dosing of micronized powders

Powder at the centre of consideration
The behavior of powders is determined by numerous parameters, such as particle size distribution, particle shape, particle density, melting temperature, hygroscopicity and the tendency to electrostatic charging etc. This explains the very differing behavior of the various powders, for example during feeding and dosing, and requires knowledge as exact as possible about the material to be handled. Harro Höfliger therefore offers its customers as an introduction to a joint project a powder material analysis which is then invoked as the basis for selection of the most suitable dosing system. At the same time this analysis provides valuable indications as to which environmental conditions, such as temperature and relative humidity, have to be ensured during the later processing of the powder in the machine or in the production rooms. The adhesive behavior to different materials can also already be investigated at this stage. This has a decisive influence on the material selection for all parts that come into contact with the product.

Höfliger has made a name for itself on the „micronized powder“ method during the past 10 years by developing and implementing production methods and possible solutions for its customers, as regards manufacturing and packing pharmaceutical products.In this case, a predetermined dose of powder is applicated into the lungs (pulmonary) or over the nasal mucous membrane (nasal) and distributed in the blood stream.

At Höfliger, the competence necessary for handling pharmaceutical products is combined with highly technical expertise in the sectors for process, monitoring and control engineering.If one takes the example for processing different types of micronized powder, it is possible to demonstrate how the obstacles arising during the development of a new procedure can be successfully overcome. The ability to process micronized powder and the selection for a certain dosing procedure depends largely on the physical properties of the respective powder involved.

Not until a powder has been defined and classified can the selection of one or several suitable dosing systems be made. Once the selection has been made, further steps towards developing the optimum production process can be taken. Here it is decisive that the pharmacist has authoritative involvement in the development and also plays a role in deciding what steps should be taken next. These are, for instance, questions as to whether experiments with differing dosing procedures should be undertaken or whether experimental set-ups should possibly be designed and installed. Depending on the complexity of such a development project, a step-by-step process is of decisive advantage compared to a direct machine development. This process clearly focuses on dialogue and communication with the pharmacist.

The selected dosing systems should be tested with the agent-containing original formulations, if possible. While in theory it seems to be simple to produce constant conditions, hands-on tests will show that problems can occur quite frequently, such as:

  • Tolerances in the powder production process
  • Fluctuations of the ambient environmental conditions (temperature, relative humidity)
  • Uneven distribution of the powder density
  • Change of powder structure (grain size distribution, agglomeration, desagglomeration)

Starting with the production of the powder, critical parameters must be kept within very narrow tolerances, which, however, will not automatically exclude that for example the powder density may change during the downstream filling process. This is dependent, for instance, on the time between the production and filling and on the mechanical treatment of the powder during the filling procedure. Using constructive means, influence can thereby be brought to bear at an early stage.

DISC-Filler: Novel Dosing System to Fill Dry Powder Inhaler Discs

LOGO_DISC-Füller: Innovatives Dosiersystem zum Befüllen von Trockenpulver-Inhalationsdiscs

MicroVibe TT - flexible dosing system: adaptable to powder properties and target weight

LOGO_Micro Vibe TT – flexibles Dosiersystem: anpassbar an Pulvereigenschaften und Dosierbereich

GMP test rooms


Modular capsule filling and closing machine Modu-C

LOGO_Modulare Kapselfüll- und Verschließmaschine Modu-C

Powder expertise is assigned to following product groups:

There are no entries in your notes.

Show notes


The selected entry has been placed in your notes!

If you register you can save your notes permanently and access all entries even when underway – via laptop or tablet.

You can register an account here to save your settings in the Exhibitors and Products Database and as well as in the Supporting Programme.The registration is not for the TicketShop and ExhibitorShop.

Register now

Your advantages at a glance:

  • Advantage Save your notes permanently. Use the instant access to exhibitors or products saved – mobile too, anytime and anywhere – incl. memo function.
  • Advantage The optional newsletter gives you regular up-to-date information about new exhibitors and products – matched to your interests.
  • Advantage Call up your notes mobile too! Simply log in and access them at anytime.