FrymaKoruma's CoBall®-Mill annular gap bead mill is an in-line milling system for manufacturing suspensions and other products of almost any viscosity. This mill is the ideal solution for superfine grinding of active pharmaceutical ingredients such as sterile ophthalmic medications and ointments as well as numerous cosmetics and chemical applications. Its design guarantees strict compliance with the rigorous requirements of the cGMP regulations for pharmaceutical production under aseptic conditions. The unusually narrow milling chamber is filled between 50 and 80 percent full of beads made from wear-resistant ceramic materials. The CoBall®-Mill boasts a high milling power in relation to its very small chamber and the grinding energy input can be as much as 8 kW/dm3. Users profit from extremely homogeneous results with particle sizes on the nanoscale. Thanks to the distinctive conical geometry of the rotor-stator tool, the mill inputs the milling forces directly into the product. The residence time in the milling chamber – and hence the production process overall – is therefore significantly reduced. Despite the high energy input, the process temperature can be precisely controlled because the machine has a very efficient heat exchange surface. Cooling ducts in the rotor, stator and mill cover prevent the product from overheating. Cleaning is fully automated in the form of CIP (cleaning in place), SIP (sterilisation in place) and DIP (drying in place).