26 - 28 September 2017 // Nuremberg, Germany

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Multimill System in an Isolator

LOGO_Multimill System in an Isolator

Multimill System in an Isolator

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The intelligent details are convincing

Alpine multimill systems for processing highly active pharmaceutical substances undergo continuous development to keep them abreast of increasing customer demands.

At the POWTECH trade fair, Hosokawa Alpine will exhibit an isolator with integrated multiprocessing system for operation as either a fine impact mill, an opposed jet mill or a spiral jet mill. The advantages of the multimill systems are on the one hand the reduced investment and validation costs, and on the other hand the minimal space requirement and low training requirements. With the multiprocessing system, customers are guaranteed the safe processing of pharmaceutical active substances with an OEL < 50 ng/m3. Over and above this, an isolator system with three integrated mill types for fine milling, classifying-milling and micronisation offers a high degree of flexibility for a great variety of different products and fineness values. In addition, the system can be optimised without any trouble to cope with different batch sizes by changing just a very few components. The multimill system is thus suitable for processing highly active pharmaceutical substances with batch sizes ranging from just a few grams for R&D applications right up to production-scale applications.

What's new about the configuration shown at the fair? It has a completely integrated gravimetric feed metering screw that needs no cables, no load cell and no weighbridges inside the isolator. And because the entire loss-in-weight feed control system is located in the technical zone, elaborate cleaning and decontamination of a balance inside the isolator is no longer necessary.

The system is also equipped with a completely integrated automatic product filter (patent pending). The trade-fair configuration means no rigid filter housing in the isolator, the separation of process gas and isolator gas, and no contamination of the inside isolator surfaces caused by ultrafine particles.

The milling and filtration chambers in the isolator are hermetically sealed using inflatable seals. The integrated control cabinet and the technical zone can be rinsed with air introduced under pressure. The system is laid out for use in an ATEX zone.



Alpine Picoline

LOGO_Alpine Picoline



Der neue TTD Windsichter

LOGO_Der neue TTD Windsichter

Impact mill 250 SX for sugar milling

LOGO_Feinprallmühle 250 SX für die Zuckervermahlung

Impact mill 315 UPZ in pharma design

LOGO_Feinprallmühle 315 UPZ in Pharma design

Fluidised bed opposed jet mill 800/3 AFG

LOGO_Fließbettgegenstrahlmühle 800/3 AFG

Horizontal Laboratory Agitated Ball Mill

LOGO_Horizontale Labor-Rührwerkskugelmühle

Kompaktor® ARC MS 75

LOGO_Kompaktor® ARC MS 75

Kompaktors and roller presses

LOGO_Kompaktoren und Walzenpressen

Laboratory equipment, Research and product development and quality control

LOGO_Labor, Forschung und Qualitätskontrolle

Long gap mill LGM 4 with MS classifier

LOGO_Langspaltmühle LGM 4 mit MS Sichter

Mills, jet mills

LOGO_Mühlen, Strahlmühlen



NOBILTA powder processor

LOGO_Pulverprozessor NOBILTA

Classifiers and air classifiers

LOGO_Sichter und Windsichter

Classifier mill ACM 100 CX

LOGO_Sichtermühle ACM 100 CX

Pin mill 800 CW

LOGO_Stiftmühle 800 CW

Dry agitated Ball Mill PULVIS 600-PV

LOGO_Trockene Rührwerkskugelmühle PULVIS 600-PV

Air classifier VME CC 75

LOGO_Windsichter VME CC75

Multimill System in an Isolator is assigned to following product groups:

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