The intelligent details are convincing
Alpine multimill systems for processing highly active pharmaceutical substances undergo continuous development to keep them abreast of increasing customer demands.
At the POWTECH trade fair, Hosokawa Alpine will exhibit an isolator with integrated multiprocessing system for operation as either a fine impact mill, an opposed jet mill or a spiral jet mill. The advantages of the multimill systems are on the one hand the reduced investment and validation costs, and on the other hand the minimal space requirement and low training requirements. With the multiprocessing system, customers are guaranteed the safe processing of pharmaceutical active substances with an OEL < 50 ng/m3. Over and above this, an isolator system with three integrated mill types for fine milling, classifying-milling and micronisation offers a high degree of flexibility for a great variety of different products and fineness values. In addition, the system can be optimised without any trouble to cope with different batch sizes by changing just a very few components. The multimill system is thus suitable for processing highly active pharmaceutical substances with batch sizes ranging from just a few grams for R&D applications right up to production-scale applications.
What's new about the configuration shown at the fair? It has a completely integrated gravimetric feed metering screw that needs no cables, no load cell and no weighbridges inside the isolator. And because the entire loss-in-weight feed control system is located in the technical zone, elaborate cleaning and decontamination of a balance inside the isolator is no longer necessary.
The system is also equipped with a completely integrated automatic product filter (patent pending). The trade-fair configuration means no rigid filter housing in the isolator, the separation of process gas and isolator gas, and no contamination of the inside isolator surfaces caused by ultrafine particles.
The milling and filtration chambers in the isolator are hermetically sealed using inflatable seals. The integrated control cabinet and the technical zone can be rinsed with air introduced under pressure. The system is laid out for use in an ATEX zone.