D-POT is a mixer, granulator and oscillating dryer “One Step” with high mechanical action (High Shear Mixer Granulator). Same as his peer I-POT, it can mix, granulate and dry pharmaceutical powders in different formulations, combining its blade and chopper movements. Thanks to the use of the vacuum group and heating group, it is possible to carry out the entire process in a single machine (ONE STEP) significantly reducing the risk of product contamination, reducing product loss (that can be generated during powder transfer from the granulator to an FBD) and reducing complete process time.
Drying time is now significantly reduced, a feature that was improved thanks to the use of oscillation (Tilting) that homogeneously distribute the product on the hot sides of the machine.
The use of the discharge Clapet valve (an optional), combined with that oscillation favors product flow during discharge phase. This factor privileges the efficiency of the machine by reducing product cycle time and product loss.
The new design was studied to make D-POT completely hermetic, thus ensuring the possibility of processing any type of product, from hormones to anticancer, oral contraceptives, effervescent, etc. etc.
Outstanding feature: its external shape recalls the facets of a diamond and turns D-POT into a unique machine of its kind.
Container Oscillation System to increase the surface available for heat exchange during product drying phase. The oscillation also prevents adhesion of the product, significantly reducing drying time.
Telescopic chopper adjustable in the various product ranges. Really useful when the D-POT needs to run processes with product load below its maximum.
Easily removable filter unit with possibility of extracting every single cartridge for filter sleeves replacement, the extraction is fast and simple.
Vacuum product loading system.
It is possible to install high containment loading and unloading system.
GMP design. Thanks to CNC machining, the buffer profile matches perfectly with that of the container, improving sealing performance, facilitating product discharge and evacuation of the washing liquid.
Its 3-spoke bottom blade with special design angles, generates a very high thrust, creating a specific mixing action and an excellent mechanical action on the product.
I-Cone Mill, when it is integrated into the D-POT structure, allows to calibrate dry or wet products in line. This configuration let the granules be quickly and directly processed, calibration is controlled directly from the D-POT control panel. I-Cone Mill can be CIP or WIP washing in-line, (also controlled by the D-POT control panel).
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Luperini Tailored Pharma Machinery, a division of Luperini In Excellence Group, established in 2010 and located in Lucca - Italy, designs, manufactures, and sells high technology machines, even customized ones, for the Pharmaceutical Industry processes (granulation, handling, washing and accessories) with presence all over the world.
Luperini Tailored Pharma Machinery has already launched its revolutionary COGNITIVE PHARMA MACHINERY line, that takes advantage of IIoT sensors and A.I. algorithms to perform autonomously and continuously improve its performance.
This new technology also complies with the Process Analytical Technology (PAT) guidelines, making it a practical embodiment of Pharma 4.0, the fourth industrial revolution in the Pharmaceutical Industry. This is an important step towards achieving Quality by Design (QbD) in the pharmaceutical manufacturing process.